EndNote 21.1.17328 downloading3/14/2024 However, the data synthesis revealed a statistically significant favor for the efficacy of all vaccines over placebo across all subgroups of ethnicities.Ĭonclusion: The covid-19 vaccines have non-inferior efficacy in different ethnicities. Among different vaccines, the Asian obtained the highest efficacy with mRNA-1273 but the lowest with BNT162b2. Similarly, one RCT of each NVX-CoV2373 and AZD1222 reported the highest efficacies of the respective vaccine in Black individuals. Two RCTs showed that BNT162b2 had the highest efficacy (100%) in Black ethnicity. Compared to White participants, one RCT showed higher efficacy of mRNA-1237 in communities of color, whereas another RCT showed higher efficacy in Asians. The RCTs included in the data synthesis covered mRNA-1273, BNT162b2, NVX-CoV2373, AZD1222, and vaccines and reported 603 total events out of 125,874 participants in the interventional group and 3115 total events out of 109,093 participants in placebo groups. Results: A total of 4799 retrieved records were filtered down to 13 studies for inclusion which comprised nine RCTs, three case-control studies, and one retrospective cohort. We descriptively reviewed the included studies and performed data synthesis for randomized controlled trials (RCTs). The study followed PRISMA (Preferred Items for Reporting Systematic Reviews and Meta-analysis) guidelines for reporting systematic reviews. Method: We conducted a systematic review by using different names of EUL vaccines in Cochrane Covid-19 Study Register (CCSR) and WHO Covid‐19 global literature and exported the retrieved results to EndNote X8 to eliminate the duplicate records. Therefore, the present study aimed to evaluate the efficacy of covid-19 vaccines of Emergency Use License (EUL) in BAME ethnicities. The research has reported that the response of vaccines against different viral infections has varied among different groups of populations such as age, gender, race, and comorbidities. Background: The Black, Asian, and minority ethnic (BAME) groups are more prone to covid-19 disease severity and its associated mortality.
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